Support Your Body’s Natural Defenses Every Day

Vitamins C, D3 and E, Zinc, Elderberry and Echinacea in two daily capsules.

Trusted by 300+ Reviewers

  • ImmuneCore Defense Plus
  • ImmuneCore Defense Plus - gallery-facts
1 2
  • FDA-Registered
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  • Third-Party
    Tested
  • Science-Backed
    Formula
  • 60-Day
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Daily Immune Support

ImmuneCore Defense Plus

ImmuneCore Defense Plus

Supports Healthy Immune Function, Year-Round Resilience & Healthy Aging

4.6/5 (307 Reviews)

Benefits:

  • Supports healthy immune function
  • Supports immune readiness
  • Supports healthy vitamin D levels
  • Antioxidant protection
  • Supports healthy aging

Non-GMO · Made in the USA in a cGMP-certified facility

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  • 60-Day Money-Back Guarantee
  • Free USA Shipping Over $75
  • 250,000+ Happy Customers

How to use
Take 2 capsules daily with 6–8 oz of water. For best results, take consistently.

Supplement facts
ImmuneCore Defense Plus - gallery-facts

Shipping & returns

Free US shipping on orders of $75 or more. Orders are usually processed within 1–3 business days and arrive in 3–7 business days in the US (usually 7–15 business days to other countries). 60-day money-back guarantee. See our Shipping Policy for details.

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  • Money-back guaranteeWithin 60 days of delivery
  • Fast & free shippingOn US orders of $75 or more
  • Save up to 25%On 3-month supplies & bundles
  • 250,000+ customersSatisfied and counting

Your Defenses Need Daily Support

Your immune system works around the clock, and it relies on a steady supply of key nutrients to do its job. Yet many adults run low on vitamin D, especially in darker months, and on zinc as they age.

ImmuneCore Defense Plus combines nine immune-supporting nutrients — Vitamins C, D3, E and B6, Zinc, Elderberry, Echinacea, Citrus Bioflavonoids and L-Lysine — in two daily capsules.

Many of our customers use ImmuneCore Defense Plus daily to address:

  • Seasonal changes
  • Busy, stressful weeks
  • Travel
  • Low vitamin D
  • Healthy aging goals
  • Feeling run down
  • Low zinc intake
  • Year-round wellness
Buy now
4.6/5 (307 Reviews)

Feel the difference your very first day!

Join thousands of people now feeling the difference with ImmuneCore Defense Plus!

  • Linda Linda's Story “I take it every morning and I feel ready for whatever the season brings.”
  • Frank Frank's Story “Small capsule, easy to remember. My wife and I both take it.”
  • Rosa Rosa's Story “I travel a lot for work, so this is part of my routine now.”
  • Carol Carol's Story “My grandkids keep me busy. This is part of my morning so I can keep up.”
  • Jim Jim's Story “Easy to take with breakfast. I like knowing I have my bases covered.”
See All Reviews
ImmuneCore Defense Plus

Nine Nutrients for Everyday Defense

  • Supports healthy immune function with Vitamin C and Zinc
  • Supports immune readiness with Elderberry and Echinacea
  • Supports healthy vitamin D levels with 1,600 IU of Vitamin D3
  • Antioxidant protection with Vitamin E and Citrus Bioflavonoids
  • Supports healthy aging and year-round resilience
  • Just two capsules a day

Key ingredients: Vitamin C, Vitamin D3, Zinc, Elderberry and Echinacea.

Why ImmuneCore Defense Plus works

Your immune system depends on a steady supply of a few key nutrients, and many adults fall short on vitamin D and zinc, especially in winter. A simple, well-dosed daily formula is an easy way to cover those gaps.

I like that this one pairs key vitamins and zinc with well-known botanicals like elderberry and echinacea.

See the science

Real People. Real Results.

Join thousands who are getting back their energy, focus and drive

  • I started taking it before the cold season and stuck with it. Easy to take, and I like that it has vitamin D and zinc together.

    Helen M.

    Verified Buyer

  • I teach and am around sick kids all winter. Took ImmuneCore all season and felt great.

    Ronald S.

    Verified Buyer

  • Has vitamin C, D3, zinc and elderberry in one. I replaced three separate bottles with this.

    Cheryl A.

    Verified Buyer

  • I travel for work. ImmuneCore is part of my routine before every trip.

    Vern T.

    Verified Buyer

  • With two kids bringing everything home from school, I take this all winter.

    Gina M.

    Verified Buyer

  • I am on my feet most of the day at work and this has made a real difference in how I feel by the evening.

    Patricia E.

    Verified Buyer

  • I was skeptical, but within a few weeks I could tell something was different. Easy to take and the subscription saves me money.

    Robert K.

    Verified Buyer

  • Part of my routine now. I do not even think about it anymore. Feel more like myself.

    Dennis H.

    Verified Buyer

  • I had a question about my subscription and the team answered within an hour.

    Sharon L.

    Verified Buyer

  • This is the first one where I actually noticed results. Worth every penny.

    Gary M.

    Verified Buyer

Ingredients That Bring Results

Vitamin C

Vitamin C

Antioxidant vitamin that supports the normal function of immune cells.

ImmuneAntioxidant
Vitamin D3

Vitamin D3

The sunshine vitamin, which supports healthy immune function, bones and muscles.

ImmuneBones
mock-ingredient-zinc

Zinc

Essential mineral that supports normal hormone function.

HormonesImmunity
Elderberry

Elderberry

Dark berry rich in anthocyanins, traditionally used to support immune health.

ImmuneAntioxidant
Echinacea

Echinacea

Flowering herb traditionally used to support the body’s natural defenses.

Immune
Citrus Bioflavonoids

Citrus Bioflavonoids

Plant compounds from citrus that work alongside vitamin C as antioxidants.

ImmuneAntioxidant

Stay Ready All Year

Daily support for the defenses you rely on.

1
Everyday defense

Everyday defense

Vitamin C and zinc support the normal function of immune cells.

2
Immune readiness

Immune readiness

Elderberry and echinacea support the body’s natural first line of defense.

3
Healthy aging

Healthy aging

Vitamins D3 and E support healthy immune function as you age.

What to expect

Build Your Defenses Every Day

Individual results vary.

  1. Day 1

    Nutrient support

    Vitamin C, D3 and zinc begin topping up your daily intake.

  2. Week 2

    Immune readiness

    Elderberry and echinacea support the immune cells that act first.

  3. Day 30

    Steady levels

    Daily use helps keep vitamin D and zinc levels steady.

  4. Day 90

    Year-round resilience

    Consistent support for healthy immune function as you age.

ImmuneCore Defense Plus
Why choose us

How We Compare

ImmuneCore Defense Plus Other Brands
Nine immune-supporting nutrients
Elderberry (500 mg) & Echinacea (200 mg)
Vitamin D3 (1,600 IU)
Vitamin E & Citrus Bioflavonoids
Two capsules a day
Third-party tested every batch
60-day money-back guarantee

Save today

FAQ

What is ImmuneCore Defense Plus and how does it work?

ImmuneCore Defense Plus is a daily supplement that supports healthy immune function with vitamins C, D3, E and B6, zinc, and the botanicals elderberry and echinacea.

What ingredients are in ImmuneCore Defense Plus?

Vitamin C (180 mg), Vitamin D3 (40 mcg / 1,600 IU), Vitamin E (15 mg), Vitamin B6 (1.7 mg), Zinc (11 mg), Elderberry extract (500 mg), Echinacea extract (200 mg), Citrus Bioflavonoids (100 mg) and L-Lysine (100 mg) per 2-capsule serving.

What are elderberry and echinacea?

Two of the best-known traditional immune botanicals. Elderberry is a dark berry rich in antioxidant anthocyanins, and echinacea is a flowering herb long used to support the body’s natural defenses.

How do I take ImmuneCore Defense Plus?

Take 2 capsules daily with 6–8 oz of water.

Can I take it all year?

Yes. ImmuneCore Defense Plus is designed for daily, year-round use.

Can I take it with medication?

No. ImmuneCore Defense Plus is a dietary supplement and is not intended to diagnose, treat, cure or prevent any disease, or to replace any medication. If you take prescription medication or have a medical condition, talk with your healthcare provider before using ImmuneCore Defense Plus, and never stop or change a prescription without your doctor.

Is ImmuneCore Defense Plus safe and tested?

ImmuneCore Defense Plus is made in the USA in an FDA-registered, cGMP-certified facility, and every batch is third-party tested for purity and potency. It contains no artificial colors, flavors or preservatives.

What pairs well with ImmuneCore Defense Plus?

CellRenew NAD+ Complex. Immune support and cellular energy are two foundations of healthy aging.

60-day money-back guarantee
Our Guarantee

60 Days, 0 Worries

Your Satisfaction, Our Priority

We believe in the effectiveness of ImmuneCore Defense Plus. That's why we offer a straightforward 60-day money-back guarantee. If you're not completely satisfied with your purchase, we've got you covered. It's a risk-free way to experience the benefits of ImmuneCore Defense Plus and prioritize your well-being. Your journey to a healthier you starts here, worry-free.

Real Customers, Real Results

4.6 Based on 307 reviews
  • 5 Stars 224
  • 4 Stars 58
  • 3 Stars 15
  • 2 Stars 4
  • 1 Star 6

92% of reviewers would recommend this product to a friend

Write a Review
307 Reviews

  1. Helen M.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Part of my winter routine

    I started taking it before the cold season and stuck with it. Easy to take, and I like that it has vitamin D and zinc together.

    Was this helpful?

  2. Ronald S.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Made it through flu season

    I teach and am around sick kids all winter. Took ImmuneCore all season and felt great.

    Was this helpful?

  3. Cheryl A.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    One less thing to buy

    Has vitamin C, D3, zinc and elderberry in one. I replaced three separate bottles with this.

    Was this helpful?

  4. Dale M.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Good daily immune support

    Easy two-capsule routine. I like that it has echinacea and elderberry too.

    Was this helpful?

  5. Vern T.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Traveling with confidence

    I travel for work. ImmuneCore is part of my routine before every trip.

    Was this helpful?

  6. Gina M.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Kids are in school

    With two kids bringing everything home from school, I take this all winter.

    Was this helpful?

  7. Abe L.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Good all-in-one

    Vitamin D3 and zinc in one. Easy to remember.

    Was this helpful?

  8. Patricia E.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Helps me make it through the day

    I am on my feet most of the day at work and this has made a real difference in how I feel by the evening.

    Was this helpful?

  9. Robert K.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Noticeable within the first weeks

    I was skeptical, but within a few weeks I could tell something was different. Easy to take and the subscription saves me money.

    Was this helpful?

  10. Carol W.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Good product, slow shipping

    The product itself is great. Shipping took a few days longer than expected, which is the only reason for 4 stars.

    Was this helpful?

  11. Dennis H.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    My go-to every morning

    Part of my routine now. I do not even think about it anymore. Feel more like myself.

    Was this helpful?

  12. Sharon L.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Customer service was wonderful

    I had a question about my subscription and the team answered within an hour.

    Was this helpful?

  13. Gary M.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Better than what I used before

    This is the first one where I actually noticed results. Worth every penny.

    Was this helpful?

  14. Kenneth J.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus

    Too early to tell

    Only two weeks in. Have not noticed much yet but I will keep going and update my review.

    Was this helpful?

  15. Barbara N.

    ✓ Verified Buyer

    Reviewing ImmuneCore Defense Plus · I recommend this product

    Highly recommend

    Simple, effective, and the money-back guarantee made it an easy decision to try.

    Was this helpful?